Keck study a step towards curing cancer

first_imgResearchers from the Keck School of Medicine have found a way to genetically modify mice so the rodents’ immune systems act like human immune systems, a discovery that will impact medical testing.Doctors Weiming Yuan, Xiangshu Wen, Seil Kim and Agnieszka Lawrenczyk published the study this month in the Proceedings of the National Academy of Sciences. The research took about two years and the project will be completed within four years.Yuan, the project’s chief investigator, began work on the mice a few years ago, after he recognized that current clinical trials were not successful. Yuan attributed this to minor differences between human and rodent immune systems. This difference led him to attempt to humanize the mouse model.“Making a mouse is a challenging project,” Yuan said. “This will be helping a lot of scientists to further clinical trials.”The mice contribute to research toward finding better treatments for cancer. When tested on mice, the drug α-GalCer successfully rid the animal of cancerous cells. The same results, however, were not obtained when the medication was used on human subjects, showing differences between the two species’ immune systems.The mice modification project required the successful insertion of a new functioning gene. This type of modification is far more challenging than so-called “knock-out” genetic modification, which is modification that works by eliminating a gene’s function. Yuan said the next step will be to further humanize the T-cell receptor, which activates lymphocytes that initiate immune system responses.The team used the difficulty of the project as motivation to succeed. Yuan said they were all very enthusiastic about their research despite difficulty working with the small size of their grant.“[We] definitely needed more funding — it’s the practical challenges,” Yuan said. “Lots of scientists are concerned about the funding situation.”The team hopes to further their work in the humanization of the rodents’ immune system.“We will branch out, but right now we have more work to further humanize the mice,” Yuan said. “We still have quite a lot of work to do before we branch out.”The dedication and enthusiasm of the team is only gaining momentum. “The future model will be even more reliable,” Yuan said.last_img read more

Iwobi: Arsenal Nearly Released me as a Teenager

first_imgAlex Iwobi has lifted the lid on just how close he was to being released by Arsenal as a teenager, revealing he was “almost” let go at 14.Iwobi joined Arsenal’s youth ranks in 2004, spending nine years in the set-up before appearing on the first-team’s bench in 2013. However it wasn’t until last season that the 20-year-old made his breakthrough under Arsene Wenger, featuring in eight of their last nine Premier League games, making 13 appearances in total.Such was his impact, Iwobi has now established himself in the Gunners’ squad, looking to continue his development at the club for the long-term. His journey to the first-team was a perilous one though, as the Nigerian international admitted he could’ve been released on a couple of occasions in the past. “I was almost released at 14, again at 16 and just about got a professional contract after that,” Iwobi told the London Evening Standard. “Especially at 14, I thought I was very close to not making it. It was stressful as I was going through school, trying to balance that and make sure I was still signed for Arsenal.“It was really difficult for me. We usually found out in December who might be kept on but I kept on getting the question ‘is he good enough?’ So they extended it to see if I could do something and it went to March and then April. Luckily I did enough.“At 16 I got the option to leave but I always felt at home at Arsenal and that was where I wanted to be. At 16, there were a lot of good players, a few internationals in the team at a young age so it was difficult for me to stand out in the games. They always want the best and I wasn’t really up there at that age.“The fact that I kept getting chances makes me feel lucky,” he disclosed to Papilonews.com yesterday.Iwobi has created six chances and won 58% of his average duels in four Premier League appearances this season, with a shot accuracy of 100%, as Arsenal sit third on 13 points from their opening six fixtures, one behind Tottenham Hotspur in second and five adrift of leaders Manchester City.Next up for them is an away clash at Burnley this weekend, before taking on Swansea City following the international break.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegramlast_img read more

How much testosterone is too much for a female athlete?

first_imgThe Caster Semenya caseSouth Africa | DANIEL KELLY | The South African athlete, Caster Semenya, has lost her case against the athletic governing body, IAAF, which means that she will have to take medication to lower her testosterone levels if she wishes to continue competing internationally in running events.Last year, the IAAF introduced new regulation for female athletes with “difference of sexual development” (DSD). Athletes with circulating testosterone of five nanomoles per litre of blood (5nmol/L) or above and who are androgen-sensitive, have to meet certain criteria if they wish to compete internationally. One criterion is that DSD athlete must use medication to reduce their blood testosterone level to below 5nmol/L for a continuous period of at least six months.Semenya felt that the IAAF was targeting her, specifically. She took her case to the Court of Arbitration for Sport (CAS), but the court rejected the 28-year-old athlete’s challenge against the IAAF’s new rules. Although CAS found the rules to be discriminatory, it also said that they were “necessary, reasonable and proportionate”.Difference of sexual developmentSo what exactly is DSD and does a serum testosterone level above 5nmol/L really confer an unfair advantage in running events? DSDs are a group of rare conditions that are acquired before birth, where the reproductive organs and genitals don’t develop as expected. While the condition can be inherited, it usually occurs at random.A person with DSD may have a mix of both male and female sexual characteristics. For example, they may be genetically female, but with reproductive organs that are of the opposite sex (or the other way around), a combination of both male and female, or not clearly either.As the testes are the primary site of testosterone production, if a female is born with these male reproductive organs, their testosterone level will be high, often reaching male levels. Testosterone is involved in many factors that may confer athletic benefit including increased muscle size and strength, along with the ability for the blood to deliver oxygen to those working muscles. This is why elite male athletes are generally faster and stronger than females – and also why males don’t compete against females in most sports. Semenya has high levels of testosterone so she will undoubtedly have at least some associated metabolic benefits.How much benefit testosterone gives female athletes is difficult to define as women cannot convert testosterone into its more potent form and do not possess the same numbers of testosterone receptors (to carry out its actions) as men. The IAAF level of 5nmol/L is still high for female levels, which normally range from 0.1 – 1.8nmol/L. Judging the actual benefit of testosterone and where to draw these lines would require a lot more research and investigation.Where does it stop?However, Semenya hasn’t artificially altered her testosterone levels and while her condition is rare – and gives her a large advantage as a track athlete, they are naturally occurring – so is it not discrimination to make her change her body to compete? Does this take the phrase “all men are equal” to the extreme and try to make everyone the same, even by artificial measures? And where does this stop? Many genetic physical attributes can contribute to athletic performance such as height, muscle composition and aerobic capacity.Dutee Chand, the female sprinter who was also barred from competing against women in 2014 because her natural levels of testosterone exceeded guidelines for female athletes, publicly expressed her disbelief as to why she was penalised for her natural body when she competes against women who are taller and from wealthier backgrounds, which certainly put them at an advantage.Cases like Semenya and Chand will always be contentious and generate more questions than solutions, and there will always be disagreement among athletes and fans over the right way to approach this sensitive issue in elite sport.****Daniel Kelly is a Lecturer in Biochemistry, Sheffield Hallam UniversityShare on: WhatsApplast_img read more

Gloucestershire’s Alison wins inaugural senior title

first_img Gloucestershire’s Alison Kelly came from four shots off the pace to become the first winner of the England Senior Women’s County Champion of Champions’ title.Kelly, from Cirencester, finished the 36-hole event at Frilford Heath Golf Club, Oxfordshire, on six-over par and won by two from Cheshire’s Barbara Jamieson (Heswall.)She was delighted to win the inaugural competition, commenting: “I didn’t know when I entered the senior championship in Gloucestershire that this would happen so it was a real bonus.“I don’t usually play in the bigger senior events because I’m a teacher and they’re usually during term-time.” Kelly takes specialist workshops in STEM subjects – science, technology, engineering and maths – in Gloucestershire primary schools.Her win was made even more special because it was at Frilford Heath – where Kelly’s parents were members until recently – and because the trophy was presented by England Golf President-elect Jenny Clink, a stalwart of Gloucestershire women’s golf.After yesterday’s first round Kelly was four behind Jamieson, who posted an opening score of level par 70 on the Green course.Today Kelly’s plan was simple: “I just went out to have a reasonable game, I wasn’t thinking of winning particularly, but of having a tidy round.” She did exactly that, going round in two-over 72 to overtake Jamieson, who finished on eight-over. Third place went to Dorset’s Jane Southcombe (Yeovil) who finished on 10-over (77, 73).Kelly took up golf as a girl and has played in Kent, Oxfordshire – where she was runner-up five times in the county championship – and Gloucestershire. This is her third spell as senior county champion and she has also been county junior organiser and a long-standing member of the women’s team.She insists she has retired from county golf although she is planning to support the team at Women’s County Finals at Royal North Devon, later this month, when Gloucestershire will be aiming to win back the title.Click here for full resultsImage copyright Leaderboard Photography 9 Sep 2018 Gloucestershire’s Alison wins inaugural senior title Tags: Alison Kelly, Champion of Champions, County, Senior, Womenlast_img read more

SECOND ANNUAL SANTA ANITA DERBY MILLIONAIRE CONTEST TO BE OFFERED ON SANTA ANITA DERBY DAY, SATURDAY, APRIL 4

first_imgWHITTIER MAN JUST MISSED WINNING A MILLION LAST YEAR WITH CALIFORNIA CHROME ARCADIA, Calif. (April 2, 2015)–Santa Anita Park has announced that it will host its second annual Santa Anita Derby Millionaire Contest on Santa Anita Derby Day, this Saturday. Fans attending on Santa Anita Derby Day are encouraged to enter, and if their name is selected, Santa Anita will provide a $1,000 win wager on a horse in the Grade I, $1 million Santa Anita Derby. The track will provide $1,000 win bets on each horse in the race and all contestants will watch the Derby together from the Santa Anita Winner’s Circle.Whichever horse wins, the contestant keeps all the money, including the $1,000 wager and the contestant will be assigned the Santa Anita Derby winner for the Kentucky Derby. If that horse goes on to win Racing’s Triple Crown, by sweeping the Kentucky Derby, Preakness and Belmont Stakes, that lucky fan would win a $1 million jackpot.“We came very close to having a million dollar winner last year,” said Santa Anita Vice President, Marketing, Nate Newby. “Eddie Espinoza and his wife, Susan, selected California Chrome to win the Santa Anita Derby, which he did and then he obviously came very close to becoming the first Triple Crown winner since Affirmed in 1978.“This contest generated tremendous excitement last year and we’re hoping it will again this year. We’ve got some outstanding horses that are pointing to our Derby and we have to be encouraged by the fact two out of the last three winners of the Santa Anita Derby went on to win the first two legs of the Triple Crown. It’s going to be a lot of fun and we just encourage everyone to come early on April 4 and make sure they submit their entries before 2 p.m.”In addition to the $1,000 win wager April 4, Santa Anita will also provide a $7,500 win wager in the Kentucky Derby May 2 and if it wins, a $10,000 win wager in the Preakness Stakes May 16. If the horse wins both the Kentucky Derby and the Preakness, as California Chrome did last year, the contestant would be in-line for a $1 million jackpot with a win in the Belmont Stakes, to be run June 6.Santa Anita Derby Millionaire Contest participants must be present to win on April 4 and must be 18 years of age or older. Please visit santaanita.com for details. –30–last_img read more

Science Is Biased

first_img(Visited 126 times, 1 visits today)FacebookTwitterPinterestSave分享0 They admit it; you can’t get rid of bias in science. Big Science has too many problems of its own to dictate ethics to others.Science is supposed to be a better method to finding truth due to its methods and its self-correction procedures. The scientific method is supposed to provide checks against researcher bias, and peer review is supposed to guard against bias at another level. Finally, reproducibility should add a third layer of protection against bias. Sounds good in theory. It’s not working in practice.The reproducibility crisis has been recognized for years (see keyword search).  Science Magazine lifted the lid on the crisis a little higher, showing how bad it is:More than 70% of researchers have tried and failed to reproduce another scientist’s experiments, and more than half have failed to reproduce their own experiments. Those are some of the telling figures that emerged from Nature‘s survey of 1,576 researchers who took a brief online questionnaire on reproducibility in research.So much for that protection. At the peer review level, there’s more problems. Science Magazine also addressed implicit bias in peer review, recommending substantial changes in the practice (implying it has not been working up till now).At the personal bias level, “we all have it,” Marcia McNutt (editor of Science Magazine) admitted. In her view, it’s an evolutionary trait.We all have it. Implicit bias was the shorthand that allowed our distant ancestors to make split-second decisions (friend or foe?) based on incomplete information. It provided a razor-thin reaction-time advantage that could mean life or death. But today, we no longer need to assume that people who do not look or sound like us pose an immediate threat. Instead, successful organizations and people welcome those who do not necessarily look, think, and act like they do. They must overcome that implicit bias wired into the human DNA if they are to reap the benefits of diversity. To explore the extent of implicit bias in peer review, and what can be done to counter it, the American Association for the Advancement of Science (AAAS, the publisher of Science) recently convened a day-long forum of editors, publishers, funders, and experts on implicit bias in Washington, DC (see p. 1067).Questions arise at this statement. If implicit bias is wired into human DNA, it must be there to advance fitness (in McNutt’s worldview). Wouldn’t it make sense from that foundation to increase bias than try to overcome it? And Does Ms. McNutt see herself falling into the current trendy bias for diversity? Isn’t the business of science to find out the truth about nature, not worry about the trendy keywords “diversity” and “inclusion”?Another glimpse at scientific bias is seen in Chris Woolston’s piece in Nature where he shows that scientists, many of whom pride themselves on their critical thinking, get emotional when caught failing to be skeptical of their own skepticism. This was occasioned by an editorial in which science writer John Horgan accused skeptics of only picking soft targets. That stung, leading to counter-tweets by scientists. But even PZ Myers, the arch-enemy of creationism and ID, saw some light. “What Horgan did was point out that there are a lot of things to be skeptical about, and skeptics have a peculiar fondness for picking the easiest targets.” That’s bias. But which scientists would be willing to doubt their own skepticism itself?McNutt assures her members that the AAAS is working hard to overcome bias and to address the crises in peer review and reproducibility. Medical Xpress is looking at the contexts that lead to reproducibility failures. Considering the levels of failure so far, what confidence can the public have in academia’s ability to police themselves?If Big Science really believed in diversity, they would hire more conservatives. There’s no diversity in ideology in the AAAS, at Nature and in many universities. That’s a situation ripe for corruption and for intellectual blindness.Only the Christian worldview, with its Ten Commandments, can provide a moral foundation for science. That’s not to say Christians in science will always perform better. But they can account for the requirements of honesty and integrity (1/16/16) in science and in every area of investigation. People view science incorrectly if they think it has a superior path to knowledge, or the only reliable way to know things. That’s scientism, not science. Real science is mediated by fallible humans who need a moral compass.If one’s moral compass is produced by natural selection, it has no guarantees about finding the truth. For a revealing piece on the failures of “evolutionary epistemology,” read Sarah Chaffee’s piece at Evolution News & Views. Contrary to simple intuition, she shows how natural selection tends to obscure reality, not help creatures discover it. With a self-refuting worldview like “evolutionary epistemology,” science is doomed. The only rescue is a worldview that accounts for the orderliness and purposefulness of nature, from a Creator who commands, “Thou shalt not bear false witness.” That goes for historians and preachers as well as for scientists and laymen.The hopeful side of that moral dictate is that humans are indeed capable of obeying it. We can, by logical inference, know what is true and what is false. And we must.last_img read more

East Cape entrepreneurs define nation brand

first_imgFrom left, Sybert Liebenberg and Vuyo Zitumane of the Eastern Cape Tourism Agency, Dr Garth Cambray, Brand South Africa trustee Neela Hoosain, Ben Nyaumwe and Iggy Sathekge at the Port Elizabeth stakeholder summit.The second Brand South Africa Stakeholder Summit kicked off in Port Elizabeth in the Eastern Cape on 12 July 2011 with a host of representatives from government, business and civil society gathering to discuss ways to grow the nation’s reputation and competitive spirit.Initiated by the Brand South Africa and taking place in each of the nine provinces, the summits aim to increase provincial participation in the nation-branding effort and encourage active citizenship – which, in turn, will help position the country as a top investment and tourism destination.The first session was held in Johannesburg in May, with similar events taking place soon in the remaining seven provinces.“The South African brand is about the promise we are making,” said Iggy Sathekge, Brand South Africa director for stakeholder relations.“If investment communities come here are see that we do not have what we promised, there will be a gap. There’s a gap because we are not being brand ambassadors ourselves – we have to start creating these internally before we can expect other people to see us in a particular way.”Brand South Africa believes that by getting South Africans to become passionate about what the country represents, each citizen becomes an embodiment of the brand promise.“If each South African becomes excited about this, we will have 49-million ambassadors who are pushing for this particular brand,” Sathekge added.Each summit presents South Africans who, through their work and community initiatives, are already active ambassadors. These individuals epitomise the unique characteristics, or pillars, of the South African brand – ubuntu, diversity, sustainability, possibility and innovation.‘If you do it, you’ve got to do it right’Having brought the world-class Radisson hotel group to South Africa, Port Elizabeth property mogul Ben Nyaumwe is one such man.“I believe that if we have entrepreneurs in this country, we will attract investors. Here’s an example: the Radisson didn’t come and choose Port Elizabeth … there was a local entrepreneur, Ben Nyaumwe, who went to group’s operators in Brussels and said ‘hey, come and look at this amazing city of Port Elizabeth’. And they came and saw and they said ‘yes, we will partner with you’.”Nyaumwe believes this approach is an example of thinking globally, acting local. “Our products cannot be inferior, if you do it, you’ve got to do it right – or stay home.“When I started talking about establishing a five-star hotel in Port Elizabeth about six years ago, many people were sceptical. But look where we are now: we’re sitting with a hotel group in the city that operates with 80% occupancy levels right throughout the week.”Although the Radisson is now the biggest international hotel group in South Africa with branches in Johannesburg, Cape Town and the Eastern Cape, there wasn’t a single establishment in the country before Nyaumwe stepped in.“We were the pioneers. Through local innovation coming out of Port Elizabeth, and growing out of this investment, we managed to ensure that the Radisson came to Johannesburg and got a presence right opposite the Johannesburg Stock Exchange and Gautrain in Sandton. That says a lot about Port Elizabeth and the potential we have. The Radisson group came here before it went to Sandton – that’s important.”Local effort leads to top global brand Dr Garth Cambray, managing director of Makana Meadery in Grahamstown, is another brand ambassador in the Eastern Cape with a local approach and global vision.Like the name suggests, his company makes wine from fermented honey, also known as mead, which is the oldest known fermented beverage on earth having been invented in Africa 20 000 years ago.Founded in 2001 with only 15 employees, the meadery now produces up to 15 000 bottles of the drink a year, as well as stocks of mead vinegar, honey mead mustard, conventional honey and honey-based jams and marmalades.Cambray has also established a similar facility in the US, which produces 66 000 bottles of award-winning mead a year that’s sold across 38 states.But he’s making sure that the benefits of the innovation remain right where mead first came from.Through several empowerment initiatives, Makana Meadery has trained over 400 unemployed people – some as far away as the Congo – to keep bees, without which mead would never exist, and sell their honey for profit.The meadery has also helped develop the local economy of Grahamstown by ensuring that previously disadvantaged residents have a 50% stake in the venture.“In terms of the global growth of the mead industry, we’re seeing that more and more brands are available – so with that, there is an increased availability of the mead product. This is growing our local brand too. We just have to help other people make mead – like we do in the US – and they grow our brand for us. It’s a very non-aggressive marketing style, but it works. It’s all about ubuntu.”Gold was the first resource in South Africa which made the country globally competitive – the next will be the “gold in our biodiversity”, Cambray said, “and the things that symbolise this are our bees and the beverage they hep produce”.last_img read more

Magic Johnson and Isiah Thomas reconcile in emotional NBA TV special

first_imgKuzma, Lakers overcome Harden’s 51 to end Rockets’ streak Magic Johnson and Isiah Thomas made amends and embraced on a special Players Only Monthy NBA TV special. Screenshot from NBA TV Twitter account.Time heals all wounds, and for NBA legends Magic Johnson and Isiah Thomas, years of separation came to an end Tuesday (Wednesday Manila time) when the two reconciled in an emotional Players Only Monthly special on NBA TV.“This has been a tremendous day,” said Johnson. “My wife, my mother, my father have been saying y’all need to get back together. So when everybody called, I said no question we’re going to do this. And just to sit across from you and relive those moments of fun, excellence, working hard, dreaming big.”ADVERTISEMENT ”You are my brother. Let me apologize to you if I hurt you—that we haven’t been together. God is good to bring us back together,” he said as the two shared an embrace, mending the fences on what was once a blooming friendship.“Let me apologize to you. If I hurt you. That we haven’t been together.”#PlayersOnlyMonthly pic.twitter.com/nDpfDfZek8FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutout— NBA TV (@NBATV) December 20, 2017 MOST READ Read Next Don’t miss out on the latest news and information. Kammuri turning to super typhoon less likely but possible — Pagasa Do not bring these items in SEA Games venues Police teams find crossbows, bows in HK university PLAY LIST 01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City 8th Top Leaders Forum assessed the progress of public-private efforts in building climate and disaster resilient communities Asian shares slide on weak Japan data; US markets closed Johnson and Thomas were close friends in the 1980s but hit road blocks which tore them apart farther from each other.Johnson’s Lakers had a fierce rivalry with Thomas’ Detroit Pistons in the tailend of the decade, as the two teams met thrice in the NBA Finals.“When we got to the (1988 NBA) Finals, our relationship became very different. It was ok for us to be friends when we weren’t competing with the Lakers, but when we started competing with the Lakers, our friendship changed. I remember my son was born in ’88 during the NBA Finals and Magic wouldn’t even come to the hospital,” said Thomas in a previous interview with Sports Illustrated.Tensions continued to heat up when Thomas allegedly questioned Johnson’s sexuality, something which the latter expounded on the Jackie MacMullan book When the Game Was Ours. That led to Thomas being left out of the star-studded “Dream Team” which competed and won the gold medal in the 1992 Barcelona Olympics.“Isiah killed his own chances when it came to the Olympics,” wrote Johnson on the book. “Nobody on that team wanted to play with him. I’m sad for Isiah. He has alienated so many people in his life, and he still doesn’t get it. He doesn’t understand why he wasn’t chosen for that Olympic team and that’s really too bad. You should be aware when you’ve ticked off more than half of the NBA.”ADVERTISEMENT BI on alert for illegally deployed OFWs to Iraq LATEST STORIES Brace for potentially devastating typhoon approaching PH – NDRRMC Cayetano: 4 social media groups behind SEA Games ‘sabotage’ Typhoon Kammuri accelerates, gains strength en route to PH View comments Thomas admitted that he felt “blindsided” by those comments in a previous report by Sports Illustrated.Despite the rift, Thomas kept Johnson in his heart and even went out of his way to persuade the players to let Johnson, who retired in 1991 after being diagnosed with HIV, to be included in the 1992 NBA All-Star Game.“They weren’t going to let Magic play in the All-Star Game,” he bared in the same Sports Illustrated article. “All the players were coming out (against him). You know how that all got turned around? I had a meeting with all of the players— because I was president of the players’ association—and I told them not only was he going to play, but we were going to shake his hand and give him a hug. And I was the first to shake his hand and hug him and give him a kiss, to let people know that’s not how the virus is spread.”Johnson and Thomas may have long been retired, but they have not left the game they love for good.Johnson is the current president of basketball operations of the Los Angeles Lakers, while Thomas is currently serving as an analyst for NBA TV.last_img read more

Sell only NCERT books, not private publisher textbook in schools: CBSE

first_imgThe Central Board of Secondary Education (CBSE) has recently asked all its affiliated schools to sell only National Council of Educational Research and Training (NCERT) books.Moreover, the board said that ‘Tuck Shops’ inside the school premises will not be able to sell books by private publishers.Also, on the issue of selling stationary items, the board said that the ‘Tuck Shops’ will be able to sell items such as pens, pencils, copies among others, but the prices should not be more than the MRP.Use only NCERT books: Last year, schools affiliated to CBSE were asked by the board to use only NCERT books for all the classesThis step has been taken after it received reports and complaints from parents that schools were pressurizing them to buy huge number of textbooks published by others.According to TOI reports, the board feels that the NCERT books are sufficient enough as the material forms the base for not only board exams but for competitive exam like JEE. Therefore, schools need not look beyond itWhat are the views of the schools?On the other hand, school authorities have been defending the use of other publicationsAjit Prasad Jain, Senior Principal, Bhavan’s Rajaji Vidyashram, said that as the nearest NCERT godown/sale counter is based in Bengaluru, they have to wait for almost six months to procure books and so it is better to buy other textbooks that don’t veer away from the prescribed CBSE syllabusNCERT to take sole responsibility of publishing school textbooks:From the year 2018, the school textbooks will be published only by the National Council of Educational Research and Training (NCERT), while the CBSE’s role will be restricted to its original mandate of holding examinations and affiliation.advertisementAbout CBSE:CBSE was established in 1962. CBSE affiliates all Kendriya Vidyalayas, all Jawahar Navodaya Vidyalayas, private schools and most of the schools approved by central government of India. Every year, the board conducts the Class 10 and Class 12 exam in the month of March.For any query, the candidates can visit the official website.Read: CBSE directs schools to send experienced teachers or say goodbye to affiliation  Read: Washington University to mentor IIT Delhi students, signs agreementRead: National Medical Commission Bill approved by Union Cabinet, MCI to be replacedFor more updates, follow India Today Education or you can write to us at [email protected]last_img read more

No Goal, Rangers Lose to Pens, 3-2

first_imgPITTSBURGH — The Pittsburgh Penguins were given a second chance for a win — and they quickly made the most of it.Brandon Sutter scored in the fourth round of the shootout, after the Rangers thought they had won it, and Pittsburgh escaped with a wild 3-2 victory against New York on Nov. 15.“I never saw anything like it,” Penguins coach Mike Johnston said. “Most of the players didn’t see it as we were coming into the room, so then we had to scramble to get guys back on the bench.”Dan Boyle appeared to win it for the Rangers in the third round, but his goal was then disallowed after a video review showed he hit the puck a second time on a rebound.“I know I tried to stuff it between the post and his skate,” Boyle said. “I haven’t seen the replay yet. I have no idea what happened, but it’s a high to a low in a hurry.”After both teams returned from the dressing rooms, Sutter beat Henrik Lundqvist with a wrist shot. Pittsburgh’s Marc-Andre Fleury then stopped Rick Nash — tied for the NHL lead with 12 goals — to end the game for good.“Sutter was the next guy, so he was ready, but (Fleury), I give him a lot of credit because he has to come in after thinking he had lost the game,” Johnston said. “That’s tough to do, and he went out there and stopped one of the best shooters in the league.”Sidney Crosby failed to record a point in his fifth straight game against New York, but scored in the shootout. Derek Stepan had the lone shootout goal for the Rangers, but it didn’t erase the sting of the loss.“Half the guys had their sweaters off, half the sticks were packed, and it wasn’t a good goal,” Rangers’ coach Alain Vigneault said. “It was the right call. We had to come back, and they won it.”Evgeni Malkin scored his seventh goal, and Blake Comeau added his fourth in regulation for Pittsburgh, which has won nine of 10. The Penguins beat the Rangers five days after losing 5-0 in New York.“That was definitely our worst game, so far,” Johnston said. “It’s important to rebound when you have a tough night.”Fleury stopped 29 shots to defeat the Rangers for the first time in five games.Martin St. Louis and Lee Stempniak had goals for New York. Nash played in his 800th career game and recorded his 100th point with the Rangers, who have lost the past two games in shootouts.Lundqvist made 36 saves. He had won the previous four against the Penguins, including the final three of last season’s second-round playoff series when the Rangers rallied from a 3-1 hole to advance.Lundqvist stopped two breakaways in overtime. The first came against Crosby, a blocker save 20 seconds in. He turned aside Kris Letang in the final 5 seconds.The Rangers went on a 4-on-3 power play with 1:42 remaining when Rob Scuderi tripped Chris Kreider.Rangers defenseman Dan Girardi left with 6:13 remaining in the scoreless third period after a check by Malkin behind the net. He returned in overtime.“That’s the best thing to take out of this game, that (Girardi) came back,” Lundqvist said. “I was really worried that he was going to be out for a while.”The Rangers have lost six of eight — four of the losses in shootouts.“I feel like I played a really solid game and did some good things out there, but in the end, come up short in the shootout,” Lundqvist said. “There are no excuses, but it’s tough. You have to regroup.”The teams struck 15 seconds apart in the first period, Comeau opening the scoring at 14:12 with a shot that caromed in off Lundqvist’s arm. Stempniak answered when he put a bouncing rebound off Girardi’s point shot past Fleury.The Rangers took the lead less than two minutes later on St. Louis’ power-play goal.Malkin tied it at 8:09 of the second, a play that started when Nick Spaling intercepted an outlet pass in the Rangers zone. Malkin’s one-timer bounced in off Lundqvist.That tying goal set up the shootout dramatics.“You think you have two points, and you relax, but have to go back out there,” Lundqvist said. “Obviously, you have everything to lose and they have everything to win in that situation.”(DAN SCIFO)TweetPinShare0 Shareslast_img read more