Hargreaves Lansdown sales up despite weak equities

first_img Share Tuesday 19 April 2011 3:16 am More From Our Partners Florida woman allegedly crashes children’s birthday party, rapes teennypost.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgSupermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.com whatsapp Hargreaves Lansdown said its third-quarter revenue rose 36 percent on year, despite a recent slump in global equities, and the wealth manager and stockbroker saw opportunities in the new tax year.The Bristol-based company, which provides management products and services to private investors in the UK, said the value of its total assets under administration as of 31 March was 23.6 billion pounds, up six per cent from end-2010.Operating revenue for the third quarter ended 31 March was at £53.3m.“This year, earthquakes in the Pacific region, uncertainty around North Africa and the Middle East, looming spending cuts and flat stock markets should have formed a less-than-ideal backdrop for equity investment,” the company said in a statement.Hargreaves shares, which recently entered the FTSE 100 index, closed at 605 pence on Monday on the London Stock Exchange. The stock has risen ten per cent since the company in posted higher first-half profit in February. Show Comments ▼ center_img by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeTotal PastThe Ingenious Reason There Are No Mosquitoes At Disney WorldTotal PastSenior Living | Search AdsNew Senior Apartments Coming to Scottsdale (Take A Look at The Prices)Senior Living | Search AdsMoneyPailShe Was Famous, Now She Works In {State}MoneyPailMisterStoryWoman Files For Divorce After Seeing This Photo – Can You See Why?MisterStorySerendipity TimesInside Coco Chanel’s Eerily Abandoned Mansion Frozen In TimeSerendipity Timesmoneycougar.comThis Proves The Osmonds Weren’t So Innocentmoneycougar.comDrivepedia20 Of The Most Underrated Vintage CarsDrivepediaLuxury SUVs | Search AdsThese Cars Are So Loaded It’s Hard to Believe They’re So CheapLuxury SUVs | Search AdsBetterBeDrones Capture Images No One Was Suppose to SeeBetterBe whatsapp John Dunne Hargreaves Lansdown sales up despite weak equities Tags: NULLlast_img read more

Aiico Insurance Plc (AIICO.ng) Q12017 Interim Report

first_imgAiico Insurance Plc (AIICO.ng) listed on the Nigerian Stock Exchange under the Insurance sector has released it’s 2017 interim results for the first quarter.For more information about Aiico Insurance Plc (AIICO.ng) reports, abridged reports, interim earnings results and earnings presentations, visit the Aiico Insurance Plc (AIICO.ng) company page on AfricanFinancials.Document: Aiico Insurance Plc (AIICO.ng)  2017 interim results for the first quarter.Company ProfileAiico Insurance Plc is a leading insurance company in Nigeria offering life assurance and annuity, general insurance and special risk, pension management, health insurance and asset management. The company is the second-largest insurance company in Nigeria by gross premiums and has a diversified client base which includes corporations, financial institutions, governments and individuals. Life insurance products include an annuity plan, corporate savings plan, education, flexible endowment plan, group life insurance plan, income investment plan, life celebration plan, mortgage protection plan, term assurance and three payment plant. Aiico Insurance Plc has a controlling stake in Multishield Plc and a minority stake in Healthcare International Plc and Aiico Capital Plc. The company’s head office is in Lagos, Nigeria. Aiico Insurance Plc is listed on the Nigerian Stock Exchangelast_img read more

How I’d find top stock picks at cheap prices for December

first_imgSimply click below to discover how you can take advantage of this. Image source: Getty Images. Peter Stephens | Wednesday, 2nd December, 2020 I would like to receive emails from you about product information and offers from The Fool and its business partners. Each of these emails will provide a link to unsubscribe from future emails. More information about how The Fool collects, stores, and handles personal data is available in its Privacy Statement. “This Stock Could Be Like Buying Amazon in 1997” Enter Your Email Address See all posts by Peter Stephens Our 6 ‘Best Buys Now’ Shares Looking for top stock picks to buy at cheap prices could be a worthwhile use of an investor’s time. It may enable them to unearth high-quality businesses that have been overlooked by other investors. It may also mean that their holdings have greater scope for capital growth than the wider stock market.As such, by comparing companies to their sector peers, focusing on their track records and considering their long-term growth strategies, it is possible to find the most attractive buying opportunities at the present time.5G is here – and shares of this ‘sleeping giant’ could be a great way for you to potentially profit!According to one leading industry firm, the 5G boom could create a global industry worth US$12.3 TRILLION out of thin air…And if you click here we’ll show you something that could be key to unlocking 5G’s full potential…Comparing top stock picks with their peersIdentifying top stock picks could be made easier through a comparison between a company and its peers. This may provide guidance to an investor in areas such as a company’s market position and how stable its financial performance could be in future. It may mean that an investor can find the strongest businesses in a sector that have the widest economic moats. Such companies may be able to capitalise more easily on the sector’s long-term growth prospects.Furthermore, an investor may be able to identify which companies offer the best value for money on a relative basis. For example, two companies in the same sector may have very different financial positions and the sizes of their economic moats may differ greatly. However, they may trade at the same valuations. This could mean that the stronger of the two companies is among the best top stock picks on a long-term basis.Changing strategies for the long runAs well as comparing companies to their peers, analysing past performance may help an investor to unearth today’s top stock picks. The current economic environment and its outlook are very uncertain. Therefore, assessing how a company has previously adapted to similar conditions could act as a guide as to how well they may cope with a difficult 2021. If they have been able to adapt their business model to embrace change in the past, they may be worthy of a premium valuation.Furthermore, considering a company’s strategy may provide an insight into how its future financial performance may change. For example, analysing recent investor updates and annual reports may act as a guide to determine whether a company has the right strategy to improve its financial performance. It may be taking too many risks, or not enough risks, to gain a greater competitive advantage over its peers.A long-term approachOf course, today’s top stock picks may take time to produce high returns. However, by comparing their prices with historic averages, as well as those of similar companies, it is possible to determine which stocks have the most appealing long-term capital appreciation potential. Over time, they could offer the most appealing prospects of outperforming the stock market. How I’d find top stock picks at cheap prices for December Renowned stock-picker Mark Rogers and his analyst team at The Motley Fool UK have named 6 shares that they believe UK investors should consider buying NOW.So if you’re looking for more stock ideas to try and best position your portfolio today, then it might be a good day for you. Because we’re offering a full 33% off your first year of membership to our flagship share-tipping service, backed by our ‘no quibbles’ 30-day subscription fee refund guarantee. Click here to claim your copy now — and we’ll tell you the name of this Top US Share… free of charge! I’m sure you’ll agree that’s quite the statement from Motley Fool Co-Founder Tom Gardner.But since our US analyst team first recommended shares in this unique tech stock back in 2016, the value has soared.What’s more, we firmly believe there’s still plenty of upside in its future. In fact, even throughout the current coronavirus crisis, its performance has been beating Wall St expectations.And right now, we’re giving you a chance to discover exactly what has got our analysts all fired up about this niche industry phenomenon, in our FREE special report, A Top US Share From The Motley Fool.last_img read more

Episcopal dioceses, organizations join lawsuit against Trump’s border wall

first_img Rector Belleville, IL Rector Washington, DC Join the Episcopal Diocese of Texas in Celebrating the Pauli Murray Feast Online Worship Service June 27 Virtual Celebration of the Jerusalem Princess Basma Center Zoom Conversation June 19 @ 12 p.m. ET Rector Hopkinsville, KY Cathedral Dean Boise, ID Donald Trump, Submit a Job Listing Youth Minister Lorton, VA Rector Shreveport, LA Missioner for Disaster Resilience Sacramento, CA Rector Collierville, TN Priest-in-Charge Lebanon, OH In-person Retreat: Thanksgiving Trinity Retreat Center (West Cornwall, CT) Nov. 24-28 Curate Diocese of Nebraska Ya no son extranjeros: Un diálogo acerca de inmigración Una conversación de Zoom June 22 @ 7 p.m. ET Rector Pittsburgh, PA Episcopal Charities of the Diocese of New York Hires Reverend Kevin W. VanHook, II as Executive Director Episcopal Charities of the Diocese of New York Rector Smithfield, NC The Church Investment Group Commends the Taskforce on the Theology of Money on its report, The Theology of Money and Investing as Doing Theology Church Investment Group Inaugural Diocesan Feast Day Celebrating Juneteenth San Francisco, CA (and livestream) June 19 @ 2 p.m. PT Episcopal Migration Ministries’ Virtual Prayer Vigil for World Refugee Day Facebook Live Prayer Vigil June 20 @ 7 p.m. ET In July, the Supreme Court ruled that construction of the border wall could begin as litigation continued. According to U.S. Customs and Border Protection, 60 miles of the wall have been completed as of Aug. 24, 13 percent of what Trump promised to build by the end of 2020. However, Axios reported that all the new construction merely replaced pre-existing walls and fences.– Egan Millard is an assistant editor and reporter for the Episcopal News Service. He can be reached at [email protected] Featured Events Assistant/Associate Rector Morristown, NJ The Church Pension Fund Invests $20 Million in Impact Investment Fund Designed to Preserve Workforce Housing Communities Nationwide Church Pension Group Featured Jobs & Calls Remember Holy Land Christians on Jerusalem Sunday, June 20 American Friends of the Episcopal Diocese of Jerusalem [Episcopal News Service] The dioceses of Long Island and Western Massachusetts, as well as Trinity Church Wall Street and Boston-based Episcopal City Mission, have joined a lawsuit that seeks to stop President Donald Trump from redirecting federal funds to build a wall on the United States’ southern border.They and 71 other religious organizations, led by the Muslim Bar Association of New York, entered an amici curiae (or “friends of the court”) brief dated Aug. 22 in support of the lawsuit, which was filed in February by the American Civil Liberties Union on behalf of the Sierra Club and the Southern Border Communities Coalition. The suit challenges Trump’s use of emergency powers to divert funds marked for other purposes to construct a border wall after Congress refused to appropriate $5.7 billion for it. The emergency powers that Trump invoked only apply to military construction projects that are necessary to support the armed forces, the Sierra Club says.The amici brief expresses the religious groups’ concern that Trump’s use of emergency powers to access funds without congressional approval sets a dangerous precedent.“President Trump’s effort to build a wall is targeted at a specific disfavored group, namely immigrants entering the United States through the southern border. But the risks of an unchecked executive with access to unlimited funds to implement its agenda are shared by all potentially-disfavored groups. … All amici are justly concerned that the president will, if permitted, use his newfound power to re-direct appropriations to impinge on the rights of religious minorities,” the brief says.The bishops of Long Island and Western Massachusetts expressed their views on Trump’s actions in brief statements of interest.“The Bishop of the Diocese fully supports this effort for a permanent injunction to stop the administration (federal government) from mis-directing and illegally using Defense Department and Treasury funds to construct an immoral, impractical and useless border wall,” the statement from the Diocese of Long Island says. “The administration’s fixation with constructing this wall is representative of the administration’s sinful and unlawful scapegoating of asylum seekers to promote an un-American, protectionist, nationalist agenda. It must not be allowed to happen.”The Rt. Rev. Douglas Fisher, bishop of Western Massachusetts, also combined concerns about the legality of Trump’s emergency declaration and the morality of his administration’s treatment of immigrants in his statement.“The president’s use of government funds for building the southern border wall is a clear violation of the Congress’ power of the purse. The situation at our southern border may quite rightly be seen as a crisis as the president’s policy shifts have stranded asylum seekers in Mexico for an indeterminate time. The impact of his change to national policy has endangered the lives of people who seek safety here. What has been done to the children under orders from the President, is immoral and an affront to human dignity,” Fisher wrote on behalf of his diocese.Two other Episcopal organizations known for their public advocacy also signed onto the brief.“President Trump’s decision to build a wall with government funding targets those people with whom we are most called to demonstrate solidarity,” Episcopal City Mission, which facilitates action on various social justice issues in Massachusetts, wrote in its statement.Trinity Church Wall Street, in addition to outlining its opposition to Trump’s emergency declaration, listed the actions it has taken to support immigrants, refugees and asylum-seekers, including organizing trips to the border, convening a conference about migration, advocating for detention center reform, supporting individual asylum-seekers and participating in rallies and vigils, such as an overnight “tent city” in Trinity’s churchyard.The other 71 organizations who signed the brief represented Jews, Muslims and Christians of many denominations, as well as Unitarian Universalists and interfaith groups. Canon for Family Ministry Jackson, MS Rector Knoxville, TN Associate Priest for Pastoral Care New York, NY Rector/Priest in Charge (PT) Lisbon, ME center_img AddThis Sharing ButtonsShare to PrintFriendlyPrintFriendlyShare to FacebookFacebookShare to TwitterTwitterShare to EmailEmailShare to MoreAddThis Associate Rector Columbus, GA Course Director Jerusalem, Israel Submit an Event Listing Assistant/Associate Priest Scottsdale, AZ Priest Associate or Director of Adult Ministries Greenville, SC By Egan MillardPosted Aug 27, 2019 Rector (FT or PT) Indian River, MI Assistant/Associate Rector Washington, DC Submit a Press Release Rector and Chaplain Eugene, OR An Evening with Presiding Bishop Curry and Iconographer Kelly Latimore Episcopal Migration Ministries via Zoom June 23 @ 6 p.m. ET Curate (Associate & Priest-in-Charge) Traverse City, MI TryTank Experimental Lab and York St. John University of England Launch Survey to Study the Impact of Covid-19 on the Episcopal Church TryTank Experimental Lab Rector Albany, NY This Summer’s Anti-Racism Training Online Course (Diocese of New Jersey) June 18-July 16 Bishop Diocesan Springfield, IL New Berrigan Book With Episcopal Roots Cascade Books Director of Music Morristown, NJ Faith & Politics, Associate Rector for Family Ministries Anchorage, AK Seminary of the Southwest announces appointment of two new full time faculty members Seminary of the Southwest Episcopal dioceses, organizations join lawsuit against Trump’s border wall Immigration Family Ministry Coordinator Baton Rouge, LA Tags Press Release Service Director of Administration & Finance Atlanta, GA Rector Bath, NC Rector Tampa, FL Rector Martinsville, VAlast_img read more

Alan Voo House / Neil M. Denari Architects

first_img Projects United States Alan Voo House / Neil M. Denari ArchitectsSave this projectSaveAlan Voo House / Neil M. Denari Architects “COPY” Text description provided by the architects. The clients for this house renovation / extension, a couple with three daughters, are a creative, democratic unit. The father directs film trailers, the mother is a graphic designer and illustrator, while the high school / middle school / elementary school aged daughters are all immersed in their own versions of their parents visual cultures. The family have asked that 1,000 sf be added to the site in addition to the existing 1,000 sf house. Save this picture!Recommended ProductsWoodLunawoodThermowood FacadesMetallicsKriskadecorMetal Fabric – Outdoor CladdingDoorsSaliceSliding Door System – Slider S20Residential ApplicationsULMA Architectural SolutionsAir Facade Panels in Fonsanta RestaurationThe scheme leaves half of the house for the daughter’s bedrooms and incorporates the other half plus new extensions in front and back into a public zone and a private bedroom for the parents. This strategy amounts to a new 16 ft wide linear house being inserted into the existing house. Multi-toned, bright colors accentuate the new pieces which suggest a graphic expression representative of the family’s interests.Save this picture!Project gallerySee allShow lessPima County Behavioral Health Pavilion and Crisis Response Center / Cannon DesignArticlesFlying Walls / ateliermobArticles Share Houses “COPY” Architects: Neil M. Denari Architects Year Completion year of this architecture project Year:  CopyHouses•Los Angeles, United States ArchDaily Save this picture!+ 10 Share Alan Voo House / Neil M. Denari Architects 2007 ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/30586/alan-voo-house-neil-m-denari-architects Clipboard ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/30586/alan-voo-house-neil-m-denari-architects Clipboard CopyAbout this officeNeil M. Denari ArchitectsOfficeFollow#TagsProjectsBuilt ProjectsSelected ProjectsResidential ArchitectureHousesDabasLos AngelesRefurbishmentHouses3D ModelingUnited StatesPublished on August 03, 2009Cite: “Alan Voo House / Neil M. Denari Architects” 03 Aug 2009. ArchDaily. Accessed 12 Jun 2021. ISSN 0719-8884Read commentsBrowse the CatalogPanels / Prefabricated AssembliesTechnowoodSiding Façade SystemWindowsMitrexSolar WindowMetal PanelsAurubisCopper Surface: Nordic DécorDining tablesB&B ItaliaDining Table – BullSkylightsVELUX CommercialModular Skylights – Atrium Longlight / RidgelightLouvers / ShuttersBruagShading Screens – Perforated Facade PanelsConcreteKrytonSmart ConcreteCompositesPure + FreeFormTechnical Guide – Creating a Seamless Interior and Exterior Material TransitionEnclosures / Double Skin FacadesFranken-SchotterFacade System –  LINEAWindowsRabel Aluminium SystemsMinimal Casement Windows – Rabel 8400 Slim Super Thermal PlusDoorsGorter HatchesFloor Door – Fire RatedWire MeshCarl Stahl DecorCableGreen Wall System – FAÇADESCAPE™More products »Read commentsSave想阅读文章的中文版本吗?Alan Voo住宅 / Neil M. Denari Architects是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my streamlast_img read more

L.D. Barkley — A leader in the Attica uprising

first_imgFacebookTwitterWhatsAppEmailPrintMoreShare thisFacebookTwitterWhatsAppEmailPrintMoreShare this L.D. Barkley, second from the right, and other Attica rebellion leaders negotiating with prison officials, Sept. 1971.This year marks the 50th anniversary of the Attica Prison Uprising. The following slightly edited excerpt is from the book “A Time To Die: The Attica Prison Revolt” by the late New York Times writer, Tom Wicker. The original publication in 1975 was followed by 1994 and 2011 editions. Wicker was a member of a negotiating team invited by the prisoners to help present their demands to the public from Sept. 9-13, the day that then New York Gov. Nelson Rockefeller ordered state police officers and prison guards to open fire for six minutes slaughtering 29 unarmed incarcerated workers and 10 guards taken hostage. Russell Oswald was New York’s Commissioner of Correctional Services.  One of those massacred was L.D. Barkley, who had emerged as an important spokesperson for the rebellion, whose role is described in the excerpt below.  Barkley was a brilliant example, similar to the martyred George Jackson, of evolving into a revolutionary activist and leader behind the walls at a young age. Barkley, like so many of his fellow Attica comrades, was tragically never allowed to realize his revolutionary potential but his inspiring words and actions will live on.   Elliot James Barkley was 21 years old, a tall Black from Rochester, New York, with a history of drug use. Convicted at 18 for cashing a forged money order for $124.60, he had been sent to the Elmira Reformatory for four years. Paroled in January 1970, he rejoined his family, who were rated good people in the Black community of Rochester; but then he was picked up for driving without a license, a violation of parole. For that, he was sent to the maximum security prison at Attica where — although he was in no real sense a leader — he became a well-known exercise-yard orator. When D-yard was or­ganized after the uprising, Barkley and Richard Clark were elected to represent A-block inmates.Roger Champen recalled:“Barkley was more close to me than any of those I’ve mentioned. Primarily because he’s younger and the fact that I relate to younger people more readily than older ones, because of the fact that I figured if I had had someone to tell me the things that I know now, perhaps I would have looked at life differently earlier.  So I tried primarily to reach out for the younger element.“[B]arkley and I used to read. I gave him law books. I tried to get him involved in law. He was an excellent reader. He would read; he would have an appetite for reading that was tremendous. He would come and get books from me to read, and then we’d sit down and discuss it. [B]eing that he was young and inexperi­enced, books — I tried to explain to him — were just an outline of life. You had to actually live life; you couldn’t live like out of a book. The book gives you the diagram for life, the outline, and you fill in the rest for yourself. . . .“And he was eager to get back outside, to go in the community and work in the community. He felt that he could help younger children.”If Russell Oswald did not know L.D. Barkley — no one in Rochester or in Attica seems to know how Elliot James Barkley became known as “L.D.” — when Oswald first entered the D-yard stronghold, he surely did when he emerged from it for the second time that Thursday night, Sept. 9. Barkley, with television cameras carrying his image and words to the world, again presented the inmates’ “immediate de­mands.” More than that, with his reedy voice, his youthful face and “granny glasses,” his fiery manner and words, he conveyed the anger, the frustration, the determination that everyone who entered D-yard sensed in the inmates — at least among their active and articulate leaders.“We have composed this declaration [L.D. began] to the people of America to let them know exactly how we feel and what it is that they must do, and what we want, primarily, and not what we — what someone else wants for us. We’s talking about what we want.“[T]here seems to be a little misunderstand­ing about why this incident developed here at Attica, and this declaration here will explain the reasons.“The entire incident that has erupted here at Attica is not a result of the dastardly bushwhacking of two prisoners Sept. 8 of 1971, but of the unmitigated oppression wrought by the racist administrative network of this prison throughout the year. We are men! We are not beasts and we do not intend to be beaten or driven as such.“The entire prison populace — that means each and every one of us here — has set forth to change forever the ruthless brutalization and disregard for the lives of the prisoners here and throughout the United States. What has happened here is but the sound before the fury of those who are oppressed.“We will not compromise on any terms except those terms which are agreeable to us. We call upon all the conscientious citizens of America to assist us in putting an end to this situation that threatens the lives of not only us, but of each and every one of you as well.  We have set forth demands that will bring us closer to the reality.We want complete amnesty, meaning freedom from all and any physical, mental and legal reprisals.We want, now, speedy and safe transportation out of confine­ment to a non-imperialist country.We demand that the federal government intervene so that we will be under direct federal jurisdiction. We want the governor and the judiciary to guarantee that there will be no reprisals, and we want all facets of the media to articulate this.”Russell Oswald, hearing all this from a few feet away, decided L.D. Barkley was a “pure revolutionary.”last_img read more

Vipergen Publishes First Technology for Screening DNA-Encoded Small-Molecule Libraries (DELs) Inside Living Cells

first_img Twitter Pinterest Previous articleOAT021021_drivethru_reading_parade_Next articleGlobal Cell Based Assay & High Content Screening Markets Report 2021 with Updated COVID-19 Impact Analysis – ResearchAndMarkets.com Digital AIM Web Support COPENHAGEN, Denmark, Feb. 17, 2021 /PRNewswire/ — Vipergen ApS announced today a published study describing a powerful new drug discovery approach that enables, for the first time, screening DNA-encoded small-molecule libraries (DELs) inside living cells. The study, published in the peer-reviewed Journal of the American Chemical Society, highlights the potential of Vipergen’s Cellular Binder Trap Enrichment® (cBTE) technology to significantly expand the ability to discover novel small molecules, including against difficult-to-drug targets, and reduce attrition rates in drug discovery. Vipergen is offering its cBTE DNA-encoded library drug discovery platform as a service to biotechnology and pharmaceutical company partners to accelerate and improve their drug discovery processes. “This research validates the potential for Vipergen’s Cellular Binder Trap Enrichment platform to become a revolutionary tool in small-molecule drug discovery based on its ability to successfully screen DELs against drug targets inside living cells, with no requirement for purified active target protein,” said Nils Hansen, Ph.D., Chief Executive Officer of Vipergen. “We expect the ability to perform DEL screening under the more physiologically relevant conditions of a living cell to significantly lower attrition rates in drug discovery. Furthermore, by uniquely allowing us to eliminate the requirement for highly purified active target protein, this technology will improve timelines and bring about new options for novel drug development by allowing us to screen many more targets, prioritize those giving the most promising screening results, and screen DELs against challenging targets that are difficult to express and purify in an active form. We look forward to providing this new tool to biotechnology and pharmaceutical partners to substantially improve the efficiency and success of their small-molecule drug discovery efforts.” Screening technology plays a major role in small-molecule drug discovery, where the goal is to identify compounds that interact in a desired way with a drug target of interest to serve as starting points for drug development. Depending on the technology, conventional high-throughput screening technologies allow for testing of up to a few million molecules organized as libraries of discrete compounds. Screening campaigns are typically costly and time-consuming endeavors, from the initial conception of an assay through its translation into a format compatible with high throughput, large-scale experimentation and evaluation of results. DNA-encoded library (DEL) technologies—involving the attachment of unique DNA tags to each small molecule in a library that encodes its identity and how it was synthesized—have emerged as a game-changing tool to help overcome the significant time and cost constraints of conventional screening in drug discovery by enabling synthesizing and screening of libraries containing hundreds of millions to billions of small molecules simultaneously against a drug target of interest. The results reported in the Journal of the American Chemical Society define Vipergen’s novel system for screening DELs inside a living cell under physiologically relevant conditions and without the need for highly purified active target protein. In this research, Vipergen scientists screened a 194 million-member DEL inside live oocytes of the South African clawed frog (Xenopus laevis) against three pharmaceutically relevant protein targets. The large size of the Xenopus oocyte permitted simple injection of the DEL, overcoming the fundamental challenge of delivering DELs across cell membranes for in vivo screening. The target protein was expressed in the oocytes fused to a prey protein to allow specific DNA labeling and to discriminate between DEL members binding to the target protein and the endogenous cell proteins. The technology successfully identified and validated multiple small-molecule hits for all three drug targets. About Vipergen’s Cellular Binder Trap Enrichment®(cBTE) Technology Vipergen’s proprietary Cellular Binder Trap Enrichment®(cBTE) is the first and only technology for screening DNA-encoded small-molecule libraries (DELs) inside a living cell. The platform is designed to accelerate and improve the success rate for discovering novel, high-quality small molecules for drug development—including against challenging drug targets that are difficult to express and purify in an active form—by: Lowering drug discovery attrition rates by enabling DEL screening under the more physiologically relevant conditions of a living cellImproving drug development timelines and expanding the DEL-amenable target space by eliminating the requirement for highly purified active target protein About Vipergen ApS Vipergen is a world-leading provider of small-molecule drug discovery services based on DNA-encoded library (DEL) technologies and is the first and only company capable of screening DELs inside a living cell. Vipergen provides its proprietary suite of leading-edge DEL technologies as a service to biotechnology and pharmaceutical company partners, including top pharmaceutical companies in the U.S., EU, and Japan. For more details about Vipergen and the YoctoReactor®, Binder Trap Enrichment®, and Cellular Binder Trap Enrichment® drug discovery technology platforms, please visit www.vipergen.com. Contact: Mary Moynihan M2Friend Biocommunications 802-951-9600 [email protected] View original content: http://www.prnewswire.com/news-releases/vipergen-publishes-first-technology-for-screening-dna-encoded-small-molecule-libraries-dels-inside-living-cells-301229578.html SOURCE Vipergen WhatsApp Twitter WhatsApp Local Newscenter_img Vipergen Publishes First Technology for Screening DNA-Encoded Small-Molecule Libraries (DELs) Inside Living Cells Facebook By Digital AIM Web Support – March 4, 2021 Pinterest Facebook TAGS  last_img read more

Visiting restrictions lifted at Letterkenny General

first_img Facebook By News Highland – December 16, 2010 WhatsApp The visiting restrictions which have been in place in Surgical Ward 2 of Letterkenny General Hospital since Monday have been lifted.Hospital management is reminding visitors who may be unwell or have had vomiting or diarrhoea recently to not visit any part of the hospital.Similarly, children and those with some other serious illness should also avoid visiting the hospital. Previous articleFunding of over 940,000 euro for LYITNext articleDonegal Youth Council’s future secured News Highland Google+ WhatsApp Google+ Almost 10,000 appointments cancelled in Saolta Hospital Group this week Twitter Pinterest Newsx Advertscenter_img Twitter Visiting restrictions lifted at Letterkenny General RELATED ARTICLESMORE FROM AUTHOR Facebook Three factors driving Donegal housing market – Robinson Pinterest Calls for maternity restrictions to be lifted at LUH LUH system challenged by however, work to reduce risk to patients ongoing – Dr Hamilton Guidelines for reopening of hospitality sector published Business Matters Ep 45 – Boyd Robinson, Annette Houston & Michael Margeylast_img read more

Updated: ESB lifts threat to cut power to Letterkenny sewage system

first_img PSNI and Gardai urged to investigate Adams’ claims he sheltered on-the-run suspect in Donegal Updated: ESB lifts threat to cut power to Letterkenny sewage system Facebook Facebook Man arrested in Derry on suspicion of drugs and criminal property offences released Google+ Google+ WhatsApp Pinterest Newsx Adverts Twitter WhatsAppcenter_img Man arrested on suspicion of drugs and criminal property offences in Derry Twitter The ESB has postponed a plan to cut off power to the sewage system in College ParkLast week it emerged that College Park, Glenoughty, Willowbrook and The Elms, as well as Gaelscoil Adhamnáin and at least one other playschool are all connected to a water and sewage system that could have its power cut by the ESB on November 21st, if a bill of at least €4,400 is not paid.It is believed the bill is owed by a developer who has gone into receivership and had responsibility over the running of the pump system.Letterkenny Mayor Gerry McMonagle says he has been informed by the ESB this morning, that they have deferred cutting off the power: By News Highland – November 15, 2011 Previous articleMac Lochlainn admits delegation of 5 to Ethopia may be too manyNext articleDerry man guilty of receiving goods stolen in Donegal News Highland Dail to vote later on extending emergency Covid powers HSE warns of ‘widespread cancellations’ of appointments next week Pinterest RELATED ARTICLESMORE FROM AUTHOR 365 additional cases of Covid-19 in Republiclast_img read more

Appeal for witnesses after off licence robbery in Derry

first_img By admin – July 20, 2016 Twitter Appeal for witnesses after off licence robbery in Derry Google+ WhatsApp WhatsApp Twitter Main Evening News, Sport and Obituaries Tuesday May 25th Pinterest Facebook Further drop in people receiving PUP in Donegal Previous articleGovernment hasn’t followed through on mortgage arrears promises – DohertyNext articleNumber of patients awaiting at LUH fell sharply in June, but rose again in July admin center_img Man arrested on suspicion of drugs and criminal property offences in Derry Homepage BannerNews Google+ RELATED ARTICLESMORE FROM AUTHOR There’s been an off licence robbery in Derry.Police say last night at around 10 o’clock, a man armed with an iron bar entered the premises at Sackville Street and demanded money from staff.A small sum of cash was handed over and the man then fled the scene on foot. There were no reports of any injuries.Police are urging anyone who saw anything in the area to come forward.The man was described as being around 5’8” tall, of medium build and was wearing a white, red and navy coloured hooded top, black bottoms and black trainers. 365 additional cases of Covid-19 in Republic Facebook 75 positive cases of Covid confirmed in North Pinterest Gardai continue to investigate Kilmacrennan firelast_img read more